Glibenclamide an oral anti-hyperglycaemic agent used for the treatment of non-insulin-dependent diabetes mellitus (NIDDM). The poor water solubility and poor micromeritic properties of Glibenclamide lead to low dissolution rate and poor flow during tabletting. The aim of present study was to enhance solubility, dissolution rate and improvement of micromeritic properties of the poorly soluble drug. The parameters optimized were type, amount, and method of addition of bridging agent The spherical agglomerate/crystals of Glibenclamide was prepared by solvent change method in the presence of hydrophilic polymer in different concentration. The solvent system used was acetone, water and dichloromethane as good solvent, anti-solvent and bridging liquid respectively. Spherical agglomerates were subjected for determination of percent drug content and particle size analysis. The agglomerates were also characterized by Differential Scanning Calorimetry (DSC), Fourier Transform Infrared Spectroscopy (FTIR), X-Ray Powder Diffraction (XRD) and Scanning Electron Microscopy (SEM) analysis. The FTIR and DSC study showed no interaction between drug and polymer. XRD studies showed a slight decrease in crystallinity in agglomerates. Spherical agglomerates showed improvement in solubility, dissolution rate and micromeritic properties in comparison to that of the pure drug. The SEM also showed that the agglomerate possess a good spherical shape.
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